Creatine is a naturally occurring amino acid derivative in the human body, consisting of three amino acids: arginine, glycine and methionine. Creatine is synthesized in the human liver, and can also be ingested from food. It can rapidly increase muscle strength, accelerate fatigue recovery, and improve explosive power. The more creatine is stored in the human body, the stronger the strength and athletic ability of the person.

Various activities of the human body rely on ATP, that is, adenosine triphosphate to provide energy, and the stock of ATP in the human body is very small, ATP is quickly consumed during exercise, then creatine can quickly synthesize ATP to supply energy, which is also the main mechanism for creatine to enhance sports performance.

Synthetic creatine usually refers to creatine obtained through chemical synthesis or bioengineering techniques, which is chemically identical to naturally occurring creatine and therefore is usually similar in function and effect.

There are three main ways to synthesize creatine:

(1) Creatine was synthesized from chloroacetic acid, methylamine and cyanamide aqueous solution.

(2) It is carried out with cyanamide and sodium sarcosine or potassium sarcosine in water or in a mixture of water and organic solvents at a temperature of 20℃ ~ 150℃ and a pH of 7 ~ 14.

(3) Creatine or creatine monohydrate is prepared by reacting sodium sarcosine or potassium sarcosine with cyanamide at 20℃ ~ 150℃ and pH7.0 ~ 14.0, including pH regulation with carbonic acid.