Welcome to the Ningxia Qiyan New Materials Co., Ltd. website!
Email:Czw816@163.com 中文
Benzocaine Hydrochloride
Chemical Name: 4-Aminobenzoic acid ethyl ester hydrochloride
- Commodity name： Benzocaine Hydrochloride
Keywords:
I. Basic Information
Chemical Name: 4-Aminobenzoic acid ethyl ester hydrochloride
CAS No.: 532-32-1
Molecular Formula: C₉H₁₁NO₂·HCl
Molecular Weight: 215.65 g/mol
Appearance and Properties: White or off-white crystalline powder, odorless, slightly bitter taste, soluble in water and ethanol, aqueous solution is acidic.
II. Physicochemical Properties
Melting Point: 188–190℃ (decomposes)
Solubility: Highly soluble in water (1g/2mL) and ethanol (1g/5mL), slightly soluble in diethyl ether.
Stability: Stable in dry conditions, prone to decomposition in alkaline environments; should be stored in a light-proof, sealed container.
III. Core Applications
Pharmaceutical Field
Local Anesthetic: Blocks nerve impulse conduction, used for local analgesia in oral ulcers, sore throat, hemorrhoids, etc., and as an ingredient in external preparations (e.g., ointments, suppositories).
Pharmaceutical Excipient: Acts as an osmotic pressure regulator or pH regulator in drug formulations to improve stability and palatability.
Industrial and Research Applications
Organic Synthesis Intermediate: Used to prepare dyes, fragrances, and other fine chemicals (e.g., p-aminobenzoic acid compounds).
Analytical Reagent: Serves as a reference substance in chromatographic analysis for qualitative or quantitative detection of related compounds.
IV. Mechanism of Action
Inhibits sodium ion channels on nerve cell membranes, blocking nerve impulse conduction to produce local anesthetic effects. The hydrochloride form has better water solubility, facilitating the preparation of external or injectable formulations (must strictly follow pharmaceutical standards).
V. Quality Index Table
Test Items | Pharmaceutical Grade | Pharmaceutical Grade | Testing Method |
Assay | ≥99.0% (HPLC) | ≥99.0% (Refer to Quality Requirements for Benzocaine Used in Cosmetics) | HPLC/Titration |
Melting Point | 188 - 190°C (decomposition) | 188 - 190°C (decomposition) | Capillary Method/DSC |
pH Value | 4.5 - 6.0 | 4.5 - 6.5 (compatible with skin tolerance) | pH Meter |
Loss on Drying | ≤1.0% | ≤1.0% (to prevent moisture absorption affecting stability) | TGA/Oven Drying Method |
Residue on Ignition | ≤0.1% | ≤0.1% | Ignition Method at High Temperature |
Heavy Metals | ≤10ppm | ≤10ppm |
|
Product Inquiry
*Note: Please be sure to fill in the information accurately and keep the communication open. We will contact you as soon as possible.
Contact Information
Company Name: Ningxia Qiyan New Materials Co., Ltd
Address: Room C7, 14th Floor, Section B, Yinchuan International Trade Center, Xingqing District, Yinchuan City, Ningxia, China
Tel:0086-013909510736
Message Board