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1-Benzyl-3-hydroxypiperidine
Colorless to pale yellow crystalline solid
- Commodity name： 1-Benzyl-3-hydroxypiperidine
Keywords:
I. Basic Chemical Information
CAS Number:102931-73-7
Molecular Formula:C₁₂H₁₇NO
Molecular Weight: 191.27 g/mol
II. Physicochemical Properties
Appearance: Colorless to pale yellow crystalline solid
Melting Point: 50-55°C (literature value)
Solubility:Freely soluble in alcohols (methanol/ethanol), THF, DCM; slightly soluble in water
Stability:Protect from light and moisture; avoid strong oxidizing agents
III. Application Areas
1. Pharmaceutical Synthesis Intermediate
Neurological Drugs:** Building block for dopamine/5-HT receptor modulators (e.g., antipsychotics).
Analgesics:Synthesis of piperidine fragments for opioid molecules (e.g., fentanyl derivatives).
Anticholinergic Drugs:Used in Parkinson's disease therapeutics (e.g., benztropine analogs).
2. Chiral Synthetic Building Block
Directed Functionalization of Hydroxyl Group:
Oxidation to ketone (→ 1-Benzylpiperidin-3-one).
Halogenation reactions (→ 3-Halo-1-benzylpiperidine).
Flexibility of Debenzylation: Enables selective exposure of the nitrogen atom for modification in late-stage synthesis.
IV. Quality Standards
Test Item | Standard Requirement |
Purity | ≥98% (HPLC) |
Water Content | ≤0.5% (Karl Fischer method) |
Impurity Control |
|
Free piperidine | ≤0.2% |
Bn-deprotection product(s) | ≤0.5% |
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Contact Information
Company Name: Ningxia Qiyan New Materials Co., Ltd
Address: Room C7, 14th Floor, Section B, Yinchuan International Trade Center, Xingqing District, Yinchuan City, Ningxia, China
Tel:0086-013909510736
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