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1,4:3,6-Dianhydro-D-mannitol
White to off-white crystalline powder
- Commodity name： 1,4:3,6-Dianhydro-D-mannitol
Keywords:
I. Basic Chemical Information
Synonym: Isosorbide
CAS Number: 652-67-5
Molecular Formula: C₆H₁₀O₄
Molecular Weight:146.14 g/mol
II. Physicochemical Properties
Appearance:White to off-white crystalline powder
Melting Point:61-64°C (industrial grade); reaches 65-67°C at ≥99% purity
Solubility:Freely soluble in water, methanol, DMSO; slightly soluble in ethanol/acetone
Stability:Good acid-base resistance (pH 3-10); low hygroscopicity
III. Application Areas
1. Pharmaceutical Excipients & Drug Synthesis
Pharmaceutical Excipients:
Serves as an eco-friendly plasticizer replacing phthalates (used in sustained-release tablet coatings, capsule films).
Used to prepare **biodegradable drug carriers(e.g., nanoparticles, hydrogels).
Drug Intermediate:
Key precursor for synthesizing isosorbide dinitrate(anti-angina drug).
Building block for chiral antiviral drugs (e.g., hepatitis C protease inhibitors).
2. Polymer Material Monomer
Eco-friendly Plastics:
Polymerizes with diacids to synthesize 100% bio-based polyesters (e.g., PEF, as PET plastic substitute).
Functional Materials:
Prepares heat-resistant epoxy resin curing agents (for electronic packaging).
Synthesizes waterborne polyurethanes(eco-friendly coatings/adhesives).
3. Fine Chemicals
Chiral Synthon:Selective derivatization of hydroxyl groups (esterification, etherification).
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Contact Information
Company Name: Ningxia Qiyan New Materials Co., Ltd
Address: Room C7, 14th Floor, Section B, Yinchuan International Trade Center, Xingqing District, Yinchuan City, Ningxia, China
Tel:0086-013909510736
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