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4-Piperidinecarboxamide
White to off-white crystalline powder
- Commodity name： 4-Piperidinecarboxamide
Keywords:
I. Basic Information
Synonyms:Isonipecotamide;4-(Aminocarbonyl)piperidine; Piperidine-4-carboxamide
CAS No.:39546-32-2
Molecular Formula: C₆H₁₂N₂O
Molecular Weight:128.17 g/mol
II. Physicochemical Properties
Appearance:White to off-white crystalline powder
Melting Point:ca. 316-318°C (literature value, may decompose)
Solubility:Soluble in water, methanol, and ethanol; sparingly soluble in non-polar solvents
Stability:Stable at room temperature; hygroscopic. Store in a cool, dry place.
III. Applications
1. Pharmaceutical Synthesis Intermediate
- Core building block for CNS drugs(e.g., antipsychotics, anticonvulsants).
- Used in synthesizing kinase inhibitors(anticancer agents) and GABA receptor modulators.
- Key precursor for preparing analgesicsand neuroprotective compounds.
2. Peptidomimetics & Bioisosteres
Serves as a constrained proline analog in peptide design, enhancing metabolic stability and receptor selectivity.
3. Agrochemical R&D
Key scaffold for developing herbicides and fungicides due to its bioactive profile.
4. Chemical Synthesis
Versatile synthon: Supports N-functionalization (alkylation, acylation) and ring modifications.
Applied as a chiral auxiliary ligand in asymmetric catalysis.
IV. Product Advantages
High purity (HPLC >98%)
Multifunctionality in Drug R&D:** Combines rigid conformational control with multiple derivatization sites. Its balanced lipophilicity and hydrogen-bonding capacity make it an ideal scaffold for optimizing pharmacokinetic properties of lead compounds.
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Contact Information
Company Name: Ningxia Qiyan New Materials Co., Ltd
Address: Room C7, 14th Floor, Section B, Yinchuan International Trade Center, Xingqing District, Yinchuan City, Ningxia, China
Tel:0086-013909510736
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