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2-Pyrazinecarboxylic Acid Ethyl Ester

Colorless to pale yellow transparent liquid

  • Commodity name: 2-Pyrazinecarboxylic Acid Ethyl Ester

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I. Basic Chemical Information

Common Name:Pyrazine-2-carboxylic acid ethyl ester  

CAS Number: 17407-72-2  

Molecular Weight:152.151 g/mol  

Molecular Formula: C₇H₈N₂O₂  

II. Physicochemical Properties

Appearance:Colorless to pale yellow transparent liquid  

Boiling Point: 245-247°C (101.3 kPa)  

Density:1.162 g/cm³ (25°C)  

Refractive Index:n²⁰/D = 1.504  

Solubility:Freely soluble in ethanol, DCM, THF; slightly soluble in water  

Flash Point:*112°C (closed cup)  

III. Core Application Areas

1. Pharmaceutical Synthesis  

Key precursor for anti-tuberculosis drugs:Synthesizes **Pyrazinamide (WHO first-line anti-tuberculosis drug) via aminolysis.  

Building block for kinase inhibitors:Used in EGFR/VEGFR inhibitors (e.g., derivatives of anticancer drug Osimertinib).  

Antibacterial agent module:Constructs pyrazinone compounds against MRSA.  

2. Functional Materials  

OLED blue-light materials:Synthesizes electron transport layer materials (e.g., DPPyPz derivatives). 
Liquid crystal dopant:Prepares chiral nematic liquid crystals (display device response time <1 ms).  

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