
2-Pyrazinecarboxylic Acid Ethyl Ester
Colorless to pale yellow transparent liquid
- Commodity name: 2-Pyrazinecarboxylic Acid Ethyl Ester
Keywords:
I. Basic Chemical Information
Common Name:Pyrazine-2-carboxylic acid ethyl ester
CAS Number: 17407-72-2
Molecular Weight:152.151 g/mol
Molecular Formula: C₇H₈N₂O₂
II. Physicochemical Properties
Appearance:Colorless to pale yellow transparent liquid
Boiling Point: 245-247°C (101.3 kPa)
Density:1.162 g/cm³ (25°C)
Refractive Index:n²⁰/D = 1.504
Solubility:Freely soluble in ethanol, DCM, THF; slightly soluble in water
Flash Point:*112°C (closed cup)
III. Core Application Areas
1. Pharmaceutical Synthesis
Key precursor for anti-tuberculosis drugs:Synthesizes **Pyrazinamide (WHO first-line anti-tuberculosis drug) via aminolysis.
Building block for kinase inhibitors:Used in EGFR/VEGFR inhibitors (e.g., derivatives of anticancer drug Osimertinib).
Antibacterial agent module:Constructs pyrazinone compounds against MRSA.
2. Functional Materials
OLED blue-light materials:Synthesizes electron transport layer materials (e.g., DPPyPz derivatives).
Liquid crystal dopant:Prepares chiral nematic liquid crystals (display device response time <1 ms).
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