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2-Pyrazinecarboxylic Acid
White needle-like crystals
- Commodity name： 2-Pyrazinecarboxylic Acid
I. Basic Chemical Information
CAS Number:98-97-5
Molecular Formula: C₅H₄N₂O₂
Molecular Weight:124.1 g/mol
EINECS Number:202-718-1
II. Physicochemical Properties
Appearance: White needle-like crystals
Melting Point:222-225 °C (dec.)(lit.)
Solubility:
Soluble in hot water
Insoluble in diethyl ether, chloroform, benzene, etc.
Sublimable
III. Application Areas
1. Key Intermediate in Pharmaceutical Synthesis
Anti-tuberculosis Drugs: Core structure for synthesizing first-line drug Pyrazinamide.
Antibacterial Agents: Building block for quinolone derivatives (e.g., anti-MRSA drugs).
Anticancer Drugs:Functional module for kinase inhibitors (e.g., EGFR inhibitors).
2. Ligand and Catalyst
Metal Complexes:Acts as a bidentate ligand (N,O-donor) for preparing:
Transition metal catalysts (e.g., Cu²⁺/Zn²⁺ complexes for C-N coupling reactions).
Fluorescent probes (e.g., rare-earth metal complexes for bioimaging).
3. Organic Synthetic Building Block
Carboxyl Group Derivatization:
Esterification → Synthesis of liquid crystal material intermediates.
Reduction to alcohol → Preparation of chiral pyrazine alcohol ligands.
Decarboxylative coupling → Construction of functionalized pyrazine derivatives.
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Contact Information
Company Name: Ningxia Qiyan New Materials Co., Ltd
Address: Room C7, 14th Floor, Section B, Yinchuan International Trade Center, Xingqing District, Yinchuan City, Ningxia, China
Tel:0086-013909510736
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